There are an estimated 133,000 people living in modern slavery in Ghana (GSI 2018). Ghana remains a source, transit, and destination country for men, women, and children subjected to forced labor and sex trafficking. Ghanaian boys and girls are subjected to forced labor within the country in fishing, domestic service, street hawking, begging, portering, artisanal gold mining, quarrying, herding, and agriculture, including cocoa. Research focused on the fishing industry on Lake Volta indicated that more than half of the children working on and around the lake were born in other communities and many of these children are subjected to forced labor; not allowed to attend school; given inadequate housing and clothing; and are controlled by fishermen through intimidation, violence, and limiting access to food. Boys as young as five years old are forced to work in hazardous conditions, including deep diving, and many suffer waterborne infections. A study of the prevalence of child trafficking in selected communities in the Volta and Central Regions indicated that children from nearly one-third of the 1,621 households surveyed had been subjected to trafficking, primarily in fishing and domestic servitude.  Setsofia’s mother was suffering from ill health when she arranged for him to be trafficked to a fishing village along Lake Volta in a desperate bid to get month to treat her illness. Setsofia was just 8 years old, falsely promised an education and that he would only work part time. However he was forced to work day and night on dangerous fishing boats with little food or rest. International Needs Ghana, an FTS partner, visited Setsofia’s childhood village to talk about the need to keep children away from hazardous work and to urge slave owners to release their trafficked children. As a result of this outreach and pressure, his slave holder freed Setsofia August 12, 2016.

The museum is housed within Ussher Fort, one of three European forts built in the Accra region of Ghana during the mid-seventeenth century. Developed by Ghana's Ministry of Tourism, with support and funding from UNESCO, the museum opened in 2007.

The museum aims to highlight the history of the transatlantic slave trade in Ghana. Beginning with the development of the trade in human beings, the museum covers the history through to British abolition.

The collection is varied and includes items once used by both captors and victims. There are weapons, African household items and a model of a slave vessel. The museum also contains paintings of several key abolition figures, including William Wilberforce and Harriet Tubman.