In 1999, artist Christopher Wynter created a mosaic installation at the Cathedral Parkway subway station in Harlem. He explained that the 3-part mosaic series titled Migrations “present the ideas of uprooting, migration, and progress in symbolic form." The installation features Frederick Douglass and was placed in the subway station that runs underneath Frederick Douglass Boulevard.

In 2005, Artmakers Inc. created a large-scale political mural titled When Women Pursue Justice. During the genesis of the mural, it seemed like an overly ambitious project with little funding, and a heavy reliance on the generosity of its collaborators. Located in Brooklyn, at the busy intersection between Nostrand and Greene Avenue, the mural is populated with women who worked towards justice and social change over the last 150 years. The most visually noticeable figure on the mural is the thirty-five-foot image of Shirley Chisholm astride a golden horse and dressed in armour of African mud and kente cloth.  Surrounding Chisholm are 90 women who risked their lives and liberty to achieve voting rights, civil rights, racial justice, health and reproductive rights, and environmental justice and protection – including the abolitionists Harriet Tubman and Sojourner Truth, as well as Angela Davis, Wilma Mankiller, Margaret Sanger, and Dorothy Day.

In 2012, Mexican muralist Luis Zarate created the mural Underground Railroad on Bay Street in Sodus Point, Wayne County in upstate New York. Sponsored by the Neighborhood Association of Sodus Point, the mural depicts the involvement of Sodus Point in the Underground Railroad of the 1850s. Captain George Garlock, who captained the ship Free Trader out of Sodus Point and picked up runaway slaves on his way to Canada, is depicted in the centre of the mural on the boat between the black antislavery leaders Harriet Tubman and Frederick Douglass. On July 14, 2012, a dedication ceremony revealed a plaque was mounted below the mural that reads: “This mural depicts a scene of the Underground Railroad. From stories passed down there were several safe houses in this area that were used to harbor 'Freedom Seekers.' These included the old Cohn Farm and the old Sodus Fruit Farm and what is now Maxwell Creek B & B and Silver Waters B & B. Sometimes a schooner, out of the old Sodus Point ore dock, would pick up slaves on its way to Canada."

This mural, part of a wider series called La Lucha Continua/The Struggle Continues, is split into two halves. The bottom half shows anonymous arms merchants in suits, and the top portrait shows portraits of local residents alongside the leaders Nelson Mandela, Daniel Ortega, Robert F. Williams and the abolitionist Harriet Tubman, among others.

In 1988, Mike Alewitz designed and began to direct the creation of Pathfinder Mural in New York City’s West Village. The mural, measuring 79 x 85 feet, was an international collaboration of 80 artists from 20 different countries including Argentina, Canada, Iran, New Zealand, Nicaragua and South Africa. At its dedication, it was hailed as one of the largest political murals in the world. In 1987, Alewitz had approached the leaders of the Socialist Workers Party (SWP), of which he was a member, and proposed that Pathfinder Press sponsored a mural for its Charles Street building. The party approved both the project and his concept of the mural: a celebration of the revolutionary struggles in Cuba, Grenada, Nicaragua and South Africa, as well as in America. The central image of the mural is a large red printing press. The faces of Fidel Castro, Che Guevara, Malcolm X, Karl Marx, and Nelson Mandela loop around it. The abolitionists Frederick Douglass, Harriet Tubman and Sojourner Truth also feature. During the creation of Pathfinder Mural, the National Endowment for the Arts withdrew funding from several controversial projects, prompting a debate on free speech and censorship. For the first few months of this mural's creation, work continued without incident. But in 1989, Patrick Buchanan, a conservative commentator, vilified the mural in the Washington Times, calling it a “six-story shrine to communism, a Marxist Mount Rushmore in Greenwich Village." As the mural neared completion, the dialogue between Alewitz and the SWP started to break down. Alewitz was blocked from attending the mural dedication ceremony on November 19, 1989. During December, vandals threw glass bottles filled with white paint at the mural. In 1996, the mural was removed in order to repair cracks in exterior wall of the Pathfinder building, and by 2003, the building on which Pathfinder Mural was housed was sold for around $20 million.

As part of a Rochester WALL\THERAPY mural project in 2013, muralist Lunar New Year used Trayvon Martin, a young Frederick Douglass, and a local resident called Christopher to depict three possible paths of African American manhood in his mural I Am/Yo Soy. The young boy on the edge of the mural pleads to the North Star in the sky in a position that echoes Josiah Wedgwood’s famous 18th-century "Am I Not a Man and a Brother" medallion. An older version of Douglass then sits on the right side on the mural, as the only figure beyond the real and painted chain link fences.Lunar New Year, who is an Ecuadorian American Newark-based artist, explained that the mural is about “the history of institutionalized injustice in the USA… Injustice forged Frederick Douglass’s character, robbed Trayvon Martin of his life and [it] is up to us, to dictate what future awaits for young 7 year old Christopher from Rochester.”

Picturing Our Dreams is by incarcerated youth at the Monroe Correctional Facility in Rochester, New York. The mural was created in collaboration with a New York State Library Centre writer, visual artist and Rochester School District teachers. The ideology behind the mural was that inmates could communicate the idea that there is freedom and knowledge inside the jail system. In the centre of the mural, a heart with many key-holes floats around the corresponding keys, and above are the faces of the abolitionists Harriet Tubman and Frederick Douglass, as well as Barack Obama and Dr. Martin Luther King Jr.

This mural was painted in the Bronx, New York City by an unnamed artist and depicts Frederick Douglass in the later years of his life, and the phrase "Education is the pathway to freedom." it had been destroyed by 2016.

An unknown artist painted this mural in Harlem, New York City, on the facade of Dining Heritage. It depicts the abolitionists Frederick Douglass and Harriet Tubman, as well as Martin Luther King Jr., Rosa Parks, Jesse Jackson and Malcolm X. It was destroyed in 2015.

In 1959 the Hungarian-American illustrator and muralist Hugo Gellert created the series Seward Park Housing Murals. The four-panel mural series depicts Thomas Jefferson, Abraham Lincoln, Franklin D. Roosevelt and Albert Einstein and was commissioned by the International Ladies Garment Workers Union. The Abraham Lincoln panel has an abolitionist section that features Frederick Douglass, John Brown, Harriet Tubman, Sojourner Truth and William Lloyd Garrison.The mural was threatened with destruction many times, including in 1996 when the building residents voted to become a private co-op. Individuals on the co-op board then voted to rid the lobby of the murals that they deemed racist, ugly, socialist or 'past their time.' But the building manager, Frank Durant, insisted on their preservation.

In 2008, muralist K. Fitch painted a mural of Frederick Douglass in the abolitionist's former home town of Rochester, New York. The mural depicts Douglass in the later years of his life. It had been destoyed by 2014.

In 2014, Rochester's Shawn Dunwoody created a mural on the Interstate 490 bridge over West Main Street. It depicts the abolitionist Frederick Douglass, as well as Susan B. Anthony, Nathaniel Rochester and Austin Steward - all famous Rochester figures